What is this medicine?
MEPOLIZUMAB (me poe LIZ ue mab) is used in combination with other treatments to help treat severe asthma. It is also used for the treatment of a specific condition that causes inflammation of smaller blood vessels (vasculitis).
How should I use this medicine?
This medicine is for injection under the skin. It is given by a health care professional in a hospital or clinic setting or at home. If you get this medicine at home, you will be taught how to prepare and give this medicine. Use exactly as directed. Take your medicine at regular intervals. Do not take your medicine more often than directed.
It is important that you put your used injectors, needles and syringes in a special sharps container. Do not put them in a trash can. If you do not have a sharps container, call your pharmacist or healthcare provider to get one.
Talk to your pediatrician regarding the use of this medicine in children. While this drug may be prescribed for children as young as 6 years for selected conditions, precautions do apply.
What side effects may I notice from receiving this medicine?
Side effects that you should report to your doctor or health care professional as soon as possible:
allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue
painful rash or blisters
signs and symptoms of low blood pressure like dizziness; feeling faint or lightheaded, falls
signs and symptoms of infection like fever or chills; cough; sore throat; pain or trouble passing urine
Side effects that usually do not require medical attention (report to your doctor or health care professional if they continue or are bothersome):
What may interact with this medicine?
Interactions are not expected.
What if I miss a dose?
It is important not to miss your dose. Call your doctor of health care professional if you are unable to keep an appointment. If you give yourself the medicine and you miss a dose, take it as soon as you can. Then, take your next dose at your regular scheduled time. If it is almost time for your next dose, take only that dose. Do not take double or extra doses. If you are not sure what to do about the missed dose, call your health care professional.
Where should I keep my medicine?
Keep out of the reach of children.
If you use the vials at home, you will be instructed on how to store this medicine. Throw away any unused medicine after the expiration date on the label.
Store unopened autoinjectors and prefilled syringes in the refrigerator between 2 and 8 degrees C (36 and 46 degrees F). Do not freeze. Keep this medicine in the original container. Protect from light. Do not shake. If necessary, unopened autoinjectors and syringes can be stored out of the refrigerator at up to 30 degrees C (86 degrees F) for up to 7 days. Discard if left out of the refrigerator for more than 7 days. This medicine must be administered within 8 hours after removal from the packaging. Discard if not administered within 8 hours. Throw away any unopened, unused medicine after the expiration date on the label.
What should I tell my health care provider before I take this medicine?
They need to know if you have any of these conditions:
parasitic (helminth) infection
an unusual or allergic reaction to mepolizumab, hamster proteins, other medicines, foods, dyes, or preservatives
pregnant or trying to get pregnant
What should I watch for while using this medicine?
Tell your doctor or healthcare professional if your symptoms do not start to get better or if they get worse.
Talk with your doctor if you have not had chickenpox or the vaccine for chickenpox.
Do not stop taking your other asthma medicines unless instructed to do so by your doctor or health care professional.
Your condition will be monitored carefully while you are receiving this medicine.