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Brexanolone injection

What is this medicine?

BREXANOLONE (brex ANN oh lone) is an antidepressant. This medicine is used to treat a specific type of depression called postpartum depression. Postpartum depression occurs in some women after they give birth.

How should I use this medicine?

This medicine is for infusion into a vein. It is given by a healthcare professional in a hospital or clinic setting.

A special MedGuide will be given to you before treatment with this medicine. Be sure to read this information carefully.

Talk to your pediatrician regarding the use of this medicine in children. This medicine is not approved for use in children.

What side effects may I notice from receiving this medicine?

Side effects that you should report to your doctor or health care professional as soon as possible:

  • allergic reactions like skin rash, itching or hives; swelling of the face, lips, or tongue

  • changes in emotions or moods

  • dizziness

  • excessive drowsiness

  • fast heartbeat

  • feeling faint or lightheaded, falls

  • loss of balance or coordination

  • loss of consciousness (passing out)

  • pain, redness or irritation at site where injected

  • suicidal thoughts

  • worsening depression

Side effects that usually do not require medical attention (report these to your doctor or health care professional if they continue or are bothersome):

  • diarrhea

  • dry mouth

  • flushing of the skin or face

  • upset stomach

What may interact with this medicine?

This medicine may interact with the following medications:

  • alcohol

  • antihistamines for allergy, cough, and cold

  • certain medicines for anxiety or sleep

  • certain medicines for seizures like phenobarbital, primidone

  • general anesthetics like halothane, isoflurane, methoxyflurane, propofol

  • local anesthetics like lidocaine, pramoxine, tetracaine

  • medicines that relax muscles for surgery

  • narcotic medicines for pain

  • other antidepressants

  • phenothiazines like chlorpromazine, mesoridazine, prochlorperazine, thioridazine

What if I miss a dose?

This does not apply. This medicine is not for regular use.

Where should I keep my medicine?

This medicine is given in a hospital or clinic and will not be stored at home.

What should I tell my health care provider before I take this medicine?

They need to know if you have any of these conditions:

  • if you drink alcohol

  • kidney disease

  • suicidal thoughts, plans or attempt; a previous suicide by you or a family member

  • an unusual or allergic reaction to brexanolone, other medicines, foods, dyes, or preservatives

  • pregnant or trying to get pregnant

  • breast-feeding

What should I watch for while using this medicine?

Your condition will be monitored carefully while you are receiving this medicine. Tell your healthcare professional if your symptoms do not start to get better or if they get worse while receiving this medicine.

You may get drowsy or dizzy. During your infusion, your healthcare provider will check you for excess drowsiness every 2 hours while you are awake. It is important to tell your healthcare provider right away if you feel like you cannot stay awake during times when you are normally awake or if you feel like you are going to pass out. You must have a caregiver or family member with you to help care for your child(ren) during your infusion. After the infusion, your healthcare provider will decide when you are ready to leave the healthcare setting and return home. Do not drive, use machinery, or do anything that needs mental alertness until any feelings of drowsiness or dizziness are completely gone. Avoid alcoholic drinks; they can make you more dizzy or drowsy.

There may be a risk for abuse and dependence when using this medicine. Your healthcare provider will discuss with you the signs of abuse and dependence before treatment with this medicine.

Author: StayWell Custom Communications
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