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Diphenhydramine; Naproxen caplets

What is this medicine?

DIPHENHYDRAMINE; NAPROXEN (dye fen HYE dra meen; na PROX en) is a combination of an antihistamine sleep aid and a non-steroidal anti-inflammatory drug (NSAID). It is used to treat occasional sleeplessness with minor aches and pains.

How should I use this medicine?

Take this medicine by mouth with a full glass of water. Follow the directions on the prescription label. You can take it with or without food. If it upsets your stomach, take it with food. Take your medicine at regular intervals. Do not take it more often than directed. Do not stop taking except on your doctor's advice.

Talk to your pediatrician regarding the use of this medicine in children. While this drug may be prescribed for children as young as 12 years old for selected conditions, precautions do apply.

What side effects may I notice from receiving this medicine?

Side effects that you should report to your doctor or health care professional as soon as possible:

  • allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue

  • redness, blistering, peeling, or loosening of the skin, including inside the mouth

  • signs and symptoms of a blood clot such as chest pain; shortness of breath; pain, swelling, or warmth in the leg

  • signs and symptoms of bleeding such as bloody or black, tarry stools; red or dark brown urine; spitting up blood or brown material that looks like coffee grounds; red spots on the skin; unusual bruising or bleeding from the eyes, gums, or nose

  • signs and symptoms of a stroke like changes in vision; confusion; trouble speaking or understanding; severe headaches; sudden numbness or weakness of the face, arm or leg; trouble walking; dizziness; loss of balance or coordination

  • trouble passing urine or change in the amount of urine

  • unusually weak or tired

Side effects that usually do not require medical attention (report to your doctor or health care professional if they continue or are bothersome):

  • constipation

  • diarrhea

  • dry mouth

  • headache

  • nausea, vomiting

  • tiredness

What may interact with this medicine?

Do not take this medicine with any of the following medications:

  • cidofovir

  • ketorolac

This medicine may also interact with the following medications:

  • alcohol

  • antacids

  • antihistamines for allergy, cough and cold

  • aspirin and aspirin-like medicines

  • certain medicines for anxiety or sleep

  • certain medicines for blood pressure, heart disease, irregular heart beat

  • certain medicines for depression like amitriptyline, fluoxetine, sertraline

  • certain medicines for diabetes, like glipizide or glyburide

  • certain medicines for seizures like phenobarbital, phenytoin, primidone

  • certain medicines that treat or prevent blood clots like warfarin, enoxaparin, dalteparin, apixaban, dabigatran, and rivaroxaban

  • cholestyramine

  • cyclosporine

  • digoxin

  • diuretics

  • general anesthetics like halothane, isoflurane, methoxyflurane, propofol

  • lithium

  • local anesthetics like lidocaine, pramoxine, tetracaine

  • MAOIs like Carbex, Eldepryl, Marplan, Nardil, and Parnate

  • medicines that relax muscles for surgery

  • methotrexate

  • narcotic medicines for pain

  • other NSAIDs, medicines for pain and inflammation, like ibuprofen

  • pemetrexed

  • phenothiazines like chlorpromazine, mesoridazine, prochlorperazine, thioridazine

  • probenecid

  • sucralfate

What if I miss a dose?

If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses.

Where should I keep my medicine?

Keep out of the reach of children.

Store between 20 and 25 degrees C (68 and 77 degrees F). Throw away any unused medicine after the expiration date.

What should I tell my health care provider before I take this medicine?

They need to know if you have any of these conditions:

  • cigarette smoker

  • coronary artery bypass graft (CABG) surgery within the past 2 weeks

  • drink more than 3 alcohol-containing drinks a day

  • glaucoma

  • heart disease

  • high blood pressure

  • history of stomach bleeding

  • kidney disease

  • liver disease

  • lung or breathing disease, like asthma

  • trouble passing urine

  • prostate disease

  • stomach or intestine problems

  • an unusual or allergic reaction to diphenhydramine, naproxen, aspirin, other NSAIDs, other medicines, foods, dyes, or preservatives

  • pregnant or trying to get pregnant

  • breast-feeding

What should I watch for while using this medicine?

Visit your healthcare professional for regular checks on your progress. Tell your healthcare professional if your symptoms do not start to get better or if they get worse.

You may get drowsy or dizzy. Do not drive, use machinery, or do anything that needs mental alertness until you know how this medicine affects you. Do not stand up or sit up quickly, especially if you are an older patient. This reduces the risk of dizzy or fainting spells. Alcohol may interfere with the effect of this medicine. Avoid alcoholic drinks.

Do not take other medicines that contain aspirin, ibuprofen, or naproxen with this medicine. Side effects such as stomach upset, nausea, or ulcers may be more likely to occur. Many non-prescription medicines contain aspirin, ibuprofen, or naproxen. Always read labels carefully.

This medicine can cause ulcers and bleeding in the stomach and intestines at any time during treatment. This can happen with no warning and may cause death. Smoking, drinking alcohol, older age, and poor health can also increase risks. Call your healthcare professional right away if you have stomach pain or blood in your vomit or stool.

This medicine does not prevent a heart attack or stroke. This medicine may increase the chance of a heart attack or stroke. The chance may increase the longer you use this medicine or if you have heart disease. If you take aspirin to prevent a heart attack or stroke, talk to your healthcare professional about using this medicine.

This medicine may increase your risk to bruise or bleed. Call your healthcare professional if you notice any unusual bleeding.

This medicine may cause dry eyes and blurred vision. If you wear contact lenses, you may feel some discomfort. Lubricating eye drops may help. See your healthcare professional if the problem does not go away or is severe.

Your mouth may get dry. Chewing sugarless gum or sucking hard candy and drinking plenty of water may help. Contact your healthcare professional if the problem does not go away or is severe.

Author: StayWell Custom Communications
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